Dietetics, Nutrition and Biological Sciences Research

Dr. Douglas McBean

Senior Lecturer in Physiology & Neuroscience

Refereed Journal Publications (n=23)

Grant, L., McBean D., Fyfe, L. and Warnock, M(2009) Effects of Harpagophytum Procumbens (Devil’s Claw) on the Cyclooxygenase and Lipoxygenase Pathways of the Arachidonic Cascade. Recent Progress in Medicinal Plants, 24/11, 211-227

Grant, L., McBean D., Fyfe, L. and Warnock, M (2009) The Inhibition of Free Radical Generation by Preparations of Harpagophytum Procumbens in vitro. Phytotherapy Research, 23, 104-110

Warnock, M, McBean D ., Suter, A., Tan, J. and Whittaker, P. (2007) Effectiveness and safety of devil’s claw tablets in patients with general rheumatic disorders. Phytotherapy Research, 21, 1228-1233

Ferrington, L, Kirilly, E., McBean, D., Olverman, H.J., Bagdy, G. and Kelly, P. A. T. (2006) Persistent cerebrovascular effects of MDMA and acute responses to the drug. European Journal of Neuroscience, 24, 509-519.

Quate, L, McBean, D., Ritchie, I. M., Olverman, H.J. and Kelly, P. A. T. (2004) Acute methylenedioxymetamphetamine administration: effects upon local cerebral blood flow and glucose utilitsation in the dark agouti rat. Psychopharmacology, 173, 287-295.

Kelly, P. A. T., Ritchie, I. M., Quate, L, McBean, D. and Olverman, H.J. (2002) Functional consequences of perinatal exposure to 3,4-methylenedioxymethamphetamine in rat brain. British Journal of Pharmacology, 137, 963-970.

Kelly, P. A. T., Ritchie, I. M. and McBean, D. (2000) 7-nitroindazole reduces cerebral blood flow following chronic nitric oxide synthase inhibition. Brain Research, 885, 295-297.

McBean, D., Ritchie, I. M., Olverman, H.J. and Kelly, P. A. T. (1999) Effects of the specific serotonin reuptake inhibitor citalopram upon local cerebral blood flow and glucose utilisation in the rat. Brain Research, 847, 80-84.

McBean, D., Kelly, P. A. T. and Ritchie, I. M. (1998) Intracerebral fetal raphe implants normalize hippocampal function but not cerebrovascular control in serotonin-depleted adult rat brain. Neuroscience, 85, 63-72.

Kelly, P. A. T., McBean, D., Ritchie, I. M., Sharkey, J. and Olverman, H.J. (1995) Enhanced cerebrovascular responsiveness to hypercapnia following repeated exposure to methylenedioxyamphetamine. Journal of Cerebral Blood Flow and Metabolism, 15, 706-713.

McBean, D., Winters, V., Wilson,A, Oswald, C.B., Alps, B.J. and Armstrong, J.M. (1995) Neuroprotective effects of lifarizine (RS-87476) in a simplified rat survival model of 2 vessel occlusion. British Journal of Pharmacology, 116, 3093-3098.

Alps, B.J., Calder, C., Wilson,A, McBean, D. and Armstrong, J.M. (1995) Reduction by lifarizine of the neuronal damage induced by cerebral ischaemia in rodents. British Journal of Pharmacology, 115, 1439-1446.

Kelly, P. A. T., Ritchie, I. M., Sharkey, J. and McBean, D. (1994) Alterations in local cerebral blood flow in mature rats following prenatal exposure to cocaine. Neuroscience, 60, 185-189.

Sharkey, J., McBean, D. and Kelly, P. A. T. (1991) Acute cocaine administration: effects on both local cerebral blood flow and metabolic demand. Brain Research, 548, 310-314.

Sharkey, J., McBean, D. and Kelly, P. A. T. (1991) Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine (""Ecstasy""). Psychopharmacology, 105, 113-118.

McBean, D., Sharkey, J., Ritchie, I. M. and Kelly, P. A. T. (1991) Cerebrovascular and functional consequences of 5-HT1A receptor activation. Brain Research, 555, 159-163.

Sharkey, J., McBean, D., Ritchie, I. M. and Kelly, P. A. T. (1991) Cerebrovascular permeability in intracerebral implants of foetal basal forebrain cell suspensions. Restorative Neurology & Neuroscience, 3, 35-40.

Sharkey, J., McBean, D. and Kelly, P. A. T. (1991) Cerebrovascular responsiveness to hypercapnia in intracerebral tissue implants. Brain Research, 542, 147-150.

Sharkey, J., McBean, D., Ritchie, I. M. and Kelly, P. A. T. (1991) Normal cerebrovascular regulatory mechanisms are present in intracerebral neuronal transplants. Neuroscience, 41, 703-711.

McBean, D., Sharkey, J., Ritchie, I. M. and Kelly, P. A. T. (1990) Chronic effects of the selective serotonergic neurotoxin methylenedioxyamphetamine upon cerebral function. Neuroscience, 38, 271-275.

McBean, D., Sharkey, J., Ritchie, I. M. and Kelly, P. A. T. (1990) Evidence for a possible role for serotonergic systems in the control of cerebral blood flow. Brain Research, 537, 307-310.

McBean, D., Grome, J.J. and Rudolphi, K.A. (1989) A cerebral vasoconstrictive effect of some adenosine analogues on local cerebral blood flow and glucose utilization in the rat. Journal of Cerebral Blood Flow & Metabolism, 9, 548-555.

McBean, D., Harper, A.M. and Rudolphi, K.A. (1988) Effects of adenosine and its analogues on porcine basilar arteries: are only A2 receptors involved?. Journal of Cerebral Blood Flow & Metabolism, 8, 40-45.

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Reviews (n=20)

Grant, L., McBean, D., Fyfe, L. and Warnock, M. (2007) A Review of the Biological and Potential Therapeutic Actions of Harpagophytum Procumbens. Phytotherapy Research, 21, 199-209.

McBean, D. and Kelly, P. A. T. (1998) Rodent models of global cerebral ischaemia: a comparison of 2-vessel occlusion and 4-vessel occlusion. General Pharmacology, 30, 431- 434.

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Chapters in Books (n=13)

McBean, D. (2003) Body senses, Proprioception, Taste and Smell - Chapter 22. In Kindlen,S. (Eds.) Physiology for Health Care and Nursing, Edinburgh, United Kingdom, Churchill Livingstone, 0-443-07116-0.

McBean, D. (2003) Communicating - Chapter 26. In Kindlen,S. (Eds.) Physiology for Health Care and Nursing, Edinburgh, United Kingdom, Churchill Livingstone, 0-443-7116-0.

McBean, D. (2003) Excitable Cells: Muscle - Chapter 4b. In Kindlen,S. (Eds.) Physiology for Health Care and Nursing, Edinburgh, United Kingdom, Churchill Livingstone, 0-443-07116-0.

McBean, D. (2003) Excitable Cells: Neurones. Kindlen, S. (Ed.) Physiology for Health Care and Nursing. Edinburgh: Churchill & Livingstone, Chapter 4a., Edinburgh, Scotland, Churchill Livingstone, 0-443-071160-0.

McBean, D. (2003) Hearing - Chapter 23. In Kindlen,S. (Eds.) Physiology for Health Care and Nursing, Edinburgh, United Kingdom, Churchill Livingstone, 0-443-07116-0.

McBean, D. (2003) Learning and Memory - Chapter 28. In Kindlen,S. (Eds.) Physiology for Health Care and Nursing, Edinburgh, United Kingdom, Churchill Livingstone, 0-443-7116-0.

McBean, D. (2003) Motor Systems: An Overview - Chapter 25. In Kindlen,S. (Eds.) Physiology for Health Care and Nursing, Edinburgh, United Kingdom, Churchill Livingstone, 0-443-7116-0.

McBean, D. (2003) Pain - Chapter 29. In Kindlen,S. (Eds.) Physiology for Health Care and Nursing, Edinburgh, United Kingdom, Churchill Livingstone, 0-443-7116-0.

McBean, D. (2003) Pollution and Health - Citizen's Science: What Activists Need To Know. Redressing The Balance Handbook 5, Edinburgh, Scotland, 36-44, 1-901855-17-1.

McBean, D. (2003) Sensory Systems: An Overview - Chapter 21. In Kindlen,S. (Eds.) Physiology for Health Care and Nursing, Edinburgh, United Kingdom, Churchill Livingstone, 0-443-07116-0.

McBean, D. (2003) Sleep, Emotion and Behaviour - Chapter 27. In Kindlen,S. (Eds.) Physiology for Health Care and Nursing, Edinburgh, United Kingdom, Churchill Livingstone, 0-443-7116-0.

McBean, D. (2003) The Somatic Nervous System: An Introduction. Kindlen, S. (Ed.) Physiology for Health Care and Nursing. Edinburgh: Churchill & Livingstone, Chapter 20, Edinburgh, Scotland, Churchill Livingstone, 0-443-07116-0.

McBean, D. (2003) Vision - Chapter 24. In Kindlen,S. (Eds.) Physiology for Health Care and Nursing, Edinburgh, United Kingdom, Churchill Livingstone, 0-443-7116-0.

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Published Presentations (n=46)

Ibegbu, A, McBean, D., Fyfe, L. and Mullaney, I. (2007) (In Press) Cannabinoid Receptor Agonists'-induced effects on neuronal B50 cells in Hypoxia. Proceedings of the British Pharmacological Society at http://www.pa2online.org/

Ibegbu, A., Fyfe, L., McBean, D. and Mullaney, I. (2007) (In Press) Opioid receptor agonists - Induced changes during hypoxia in B50 neuronal cells. British Neuroscience Association Abstracts, 19.

Warnock, M. and McBean, D. (2006) Safety and tolerance of calcium pantothenate in healthy adults. Proceedings of the Nutrition Society, 65, 107.

Ferrington, L, McBean, D., Olverman, H.J. and Kelly, P. A. T. (2005) Ecstasy as a risk factor in stroke: A laboratory investigation of underlying cerebrovascular mechanisms. Journal of Cerebral Blood Flow and Metabolism, 25 (Suppl), 17.

Grant, L., McBean, D., Fyfe, L. and Warnock, M. (2005) Inhibitory effects of harpagophytum preparations on nitrite and DPPH radical.. Proceedings of the British Pharmacological Society at http://www.pa2online.org/, 2/4, 56.

Ferrington, L, McBean, D., Olverman, H.J., Leith, J.L. and Kelly, P. A. T. (2005) Local cerebral metabolic response to 8-OH-DPAT in dark Agouti rats is altered by prior exposure to 3,4,-methylenedioxymethamphetamine (MDMA). Journal of Cerebral Blood Flow and Metabolism, 25(Suppl), 582.

Ferrington, L, McBean, D., Olverman, H.J. and Kelly, P. A. T. (2005) Cerebrovascular Effects of Acute Methylenedioxymethamphetamine (MDMA) in Rats Previously Exposed To the Drug. British Neuroscience Association Abstracts, 19, 24.04.

Quate, L, McBean, D., Olverman, H.J., Leith, J.L. and Kelly, P. A. T. (2005) Previous exposure To 3,4-methylenedioxymethamphetamine (MDMA) alters the local cerebral metabolic response to 8-OH-DPAT in Dark Agouti rats.. Proceedings of the British Pharmacological Society at http://www.pa2online.org/, 2/4, 78.

Quate, L, McBean, D., Olverman, H.J. and Kelly, P. A. T. (2004) 3,4-methylenedioxymethamphetamine (MDMA) induces both acute and persistent cerebrovascular effects in Dark Agouti rats. Fundamental and Clinical Pharmacology, 18/Suppl.1, 518.

Quate, L, McBean, D., Olverman, H.J. and Kelly, P. A. T. (2004) Previous exposure to 3,4- methylenedioxy-methamphetamine (MDMA) attenuates the acute effects of citalopram upon local cerebral glucose utilization in Dark Agouti rats.. FENS Abstracts, 2, 2199.

Quate, L, McBean, D., Olverman, H.J. and Kelly, P. A. T. (2004) Previous Exposure To 3,4- methylenedioxymethamphetamine (MDMA) alters the cerebrovascular response to citalopram in Dark Agouti rats.. Fundamental and Clinical Pharmacology, 18/Suppl.1, 535.

Quate, L, McBean, D., Ritchie, I. M., Olverman, H.J. and Kelly, P. A. T. (2003) Cerebrovascular effects of acute methylenedioxymethamphetamine in rats previously exposed to the drug. British Journal of Pharmacology, 138 197P.

Quate, L, McBean, D., Olverman, H.J. and Kelly, P. A. T. (2003) Previous exposure to 3,4-methylenedioxymethamphetamine (MDMA) attenuates local cerebral metabolic responses to citalopram in dark agouti rats. Proceedings of the British Pharmacological Society at http://www.pa2online.org/ , United Kingdom, 1/4, 135.

Quate, L, McBean, D., Ritchie, I. M., Olverman, H.J. and Kelly, P. A. T. (2002) Acute methylenedioxymethamphetamine administration: effects on local cerebral blood flow and glucose utilisation in the rat. British Journal of Pharmacology, 136 63P.

Quate, L, McBean, D., Ritchie, I. M., Olverman, H.J. and Kelly, P. A. T. (2002) Chronic methylenedioxymethamphetamine administration: effects on local cerebral blood flow and glucose utilisation in the rat. British Journal of Pharmacology, 137 127P.

Kelly, P. A. T., Ritchie, I. M. and McBean, D. (1999) 7-nitroindazole reduces cerebral blood flow following chronic nitric oxide synthase inhibition. Journal of Cerebral Blood Flow and Metabolism, 19(Suppl.1) S220.

McBean, D., Ritchie, I. M. and Kelly, P. A. T. (1999) Acute inhibition of 5-HT re-uptake alters both local cerebral blood flow and glucose utilisation. Journal of Cerebral Blood Flow and Metabolism, 19 (Suppl.1) S321.

McBean, D., Ritchie, I. M. and Kelly, P. A. T. (1999) Effects of chronic methylenedioxymethamphetamine upon cerebrovascular dysfunction produced by subsequent acture exposure. Journal of Cerebral Blood Flow & Metabolism, 19 (Suppl.1) S725.

Kelly, P. A. T., Ritchie, I. M., McBean, D. and Whittle, I. R. (1999) Evidence for a neuroanatomical and neurochemical basis of peritumoural brain dysfunction. Journal of Cerebral Blood Flow and Metabolism, 19 (Suppl.1) S680.

McBean, D., Ritchie, I. M., Olverman, H.J. and Kelly, P. A. T. (1997) Alterations in cerebral functional activity following acute citalopram treatment in the rat. British Journal of Pharmacology, 122, 312.

McBean, D., Ritchie, I. M., Olverman, H.J. and Kelly, P. A. T. (1997) Effects of 5-HT1A and 5-HT1B receptor agonists upon local cerebral blood flow and glucose utilisation in the rat. British Journal of Pharmacology, 122, 308.

McBean, D., Redfern, W.S., Winters, V., Williams, A and Oswald, C.B. (1996) Further studies on the link between the loss of neuroprotective effects of lifarizine at a high dose and its hypotensive effects, using rats implanted with telemetry transducers. British Journal of Pharmacology, 117, 155.

McBean, D., Ritchie, I. M. and Kelly, P. A. T. (1995) Focal hyperaemia in rat neocortex produced by acute exposure to methylenedioxymethamphetamine. Journal of Cerebral Blood Flow & Metabolism, 15/Suppl.1, 82.

McBean, D., Winters, V., Wilson, A.D., Oswald, C.B. and Armstrong, J.M. (1995) Neuroprotective efficacy of the ion channel modulator lifarizine (RS-87476) in a rodent model of global cerebral ischaemia. British Journal of Pharmacology, 114, 331.

McBean, D., Winters, V., Wilson, A.D., Oswald, C.B. and Armstrong, J.M. (1995) The ion channel modulator lifarizine (RS-87476) reduces the size of the infarct produced in the rat by the rose Bengal photochemical focal model of cerebral ischaemia. British Journal of Pharmacology, 114, 332.

Kelly, P. A. T., McBean, D., Sharkey, J. and Ritchie, I. M. (1992) Altered cerebrovascular responsiveness to hypercapnia following serotonergic lesions: implications for our understanding of migraine. Scottish Medical Journal, 37, 92.

Sharkey, J., McBean, D., Ritchie, I. M. and Kelly, P. A. T. (1992) Exposure to the designer drug ‘ecstasy’ produces long lasting changes to hippocampal function. Scottish Medical Journal, 37, 92.

McBean, D., Sharkey, J., Ritchie, I. M. and Kelly, P. A. T. (1991) A comparison of the effects of serotonergic depletion and uptake blockade: a possible role for central 5-HT. Journal of Cerebral Blood Flow & Metabolism, 11/Suppl.2, 687.

McBean, D., Sharkey, J., Ritchie, I. M. and Kelly, P. A. T. (1991) Alterations in cerebral metabolic activity by the depletion of central serotonergic systems. Scottish Medical Journal, 36, 60.

Kelly, P. A. T., Sharkey, J. and McBean, D. (1991) Alterations in hippocampal blood flow in mature rats following cocaine exposure in utero. European Journal of Neuroscience, Suppl.4, 235.

Kelly, P. A. T., Moisan, M-P, Sharkey, J., McBean, D., Edwards, C.R.W. and Seckl, J.R. (1991) Cerebral glucose utilization following the 11ß-hydroxysteroid dehydrogenase inhibition parallels the distribution of enzyme mRNA expression. Journal of Cerebral Blood Flow & Metabolism, 11/Suppl.2, 353.

McBean, D., Sharkey, J. and Kelly, P. A. T. (1991) Cerebrovascular effects of 5-HT receptor activation. European Journal of Neuroscience, Suppl.4, 114.

Sharkey, J., Ritchie, I. M., McBean, D. and Kelly, P. A. T. (1991) Cerebrovascular responsiveness to hypercapnia in intracerebral neuronal implants. Journal of Anatomy, 176, 272.

Sharkey, J., McBean, D., Ritchie, I. M. and Kelly, P. A. T. (1991) Exposure to methylenedioxymethamphetamine (‘Ecstasy’) effects lasting alterations to hippocampal function. European Journal of Neuroscience, Suppl.4, 263.

Kelly, P. A. T., McBean, D., Sharkey, J. and Ritchie, I. M. (1991) The effect of central serotonergic lesions on the cerebrovascular response to hypercapnia. British Journal of Pharmacology, 104, 367.

McBean, D., Sharkey, J., Ritchie, I. M. and Kelly, P. A. T. (1991) The effects of the antidepressant citalopram on cerebral function. Scottish Medical Journal, 36, 60.

Sharkey, J., Philip, R., McBean, D. and Kelly, P. A. T. (1990) Acute cocaine alters both cerebral function and focal cerebrovasculature responsiveness in the rat. Neuroscience Letters Supplement, 38, 123.

McBean, D., Sharkey, J. and Kelly, P. A. T. (1990) Evidence for a possible role for central serotonergic systems in the control of cerebral blood flow. Neuroscience Letters Supplement,38, 121.

Sharkey, J., Ritchie, I. M., McBean, D. and Kelly, P. A. T. (1990) Intracerebral tissue transplantation as a model for cerebrovascular plasticity. Neuroscience Letters Supplement, 38, 124.

McBean, D., Sharkey, J. and Kelly, P. A. T. (1990) Long term effects of central serotonergic depletion upon cerebral function. Neuroscience Letters Supplement, 38, 122.

McBean, D. (1987) Effects of adenosine analogues on the cerebrovasculature and their antagonism by 8-phenyltheophylline: are only A2 receptor(s) involved? Journal of Cerebral Blood Flow & Metabolism, 7/Suppl.1, 287.

McBean, D. and Harper, A.M. (1987) Effects of adenosine and its analogues on cerebral blood flow as measured by [14C]-iodoantipyrine autoradiography and laser Doppler flowmetry. Journal of Cerebral Blood Flow & Metabolism, 7/Suppl.1, 254.

McBean, D. and Harper, A.M. (1987) Effects of adenosine and its analogues on local cerebral blood flow as measured by [14C]-iodoantipyrine (IAP) autoradiography. Scottish Medical Journal, 32, 155.

McBean, D. (1987) Effects of the adenosine analogue N6-cyclohexyladensoine (CHA) on cerebral blood flow as measured by laser Doppler flowmetry. British Journal of Pharmacology, 90/Suppl., 200.

McBean, D., Harper, A.M. and Rudolphi, K.A. (1986) Effects of adenosine analogues on the cerebrovasculature and their antagonism by 8-phenyltheophylline: identification of the receptor(s) involved. Pfluger, 407/Suppl, 31.

Skett, P. and McBean, D. (1984) The use of liver cubes in the assessment of Phase I drug metabolism in the rat. British Journal of Pharmacology, 83/Suppl.1, 400.